South Dakota Fishing

Medicine Lake

The beautiful Lake of Medicine Lake offers South Dakota anglers consistent opportunities for catching Largemouth Bass, Walleye, Northern Pike. Medicine Lake is located near western South Dakota at coordinates 42.73, -101.43. The beautiful lake provides stable water levels and diverse habitat for Largemouth Bass, Walleye, Northern Pike. Local anglers frequently report success with Largemouth Bass, Walleye, Northern Pike at Medicine Lake.

Lake South Dakota 42.7300, -101.4300
Updated 2026-04-29

Location

View on Google Maps 42.7300, -101.4300

Target Species

Largemouth BassLargemouth BassWalleyeWalleyeNorthern PikeNorthern Pike

Fishing Tips

  • Focus on dam faces during dawn when Largemouth Bass are active.
  • Focus on lily pads during first light when Largemouth Bass are active.
  • Focus on rock humps during early morning when Largemouth Bass are active.

Fishing Techniques for Medicine Lake

Focus your efforts around natural structure: points, submerged timber, weed edges, and rocky areas tend to hold fish in South Dakota lakes. Dawn and dusk are peak feeding windows, especially during warmer months when fish move shallow. A varied approach — starting fast to locate active fish, then slowing down — pays off.

What to Expect at Medicine Lake

This lake offers a scenic South Dakota setting with water clarity that varies by season and recent weather. Amenities range from improved parking and facilities at some access points to more primitive launch areas. Check conditions before heading out, especially after heavy rain.

Regulations

A valid South Dakota fishing license is required. Check South Dakota Game, Fish and Parks for current regulations.

Fishing Tips for Medicine Lake

Moon Lake

Heath Lake

Badger Lake

Frequently Asked Questions

Community areas and popular structures attract other anglers on weekends.

You can target Largemouth Bass, Walleye, Northern Pike at Medicine Lake. Largemouth Bass is particularly popular here.

pre-spawn. Many anglers find early morning and evening productive year-round.